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SYFSF inhibited renal fibrosis in DKD rats. (a–d) Immunohistochemical staining of TGF-β1, collagen IV, and fibronectin is shown. (e, f) Western blot and quantitative analysis of TGF-β1 in the cortex. SYFSF and irbesartan inhibited the expression of TGF-β1 in DKD rats. DKD + S represents the DKD rats treated with SYFSF. DKD + I represents the DKD rats treated with irbesartan. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001.
