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SYFSF serum inhibited fibrotic cytokine expression in high-glucose-treated mesangial cells. SYFSF inhibited the expression of TGF-β1, collagen IV, and fibronectin in high-glucose-treated mesangial cells. HG + S represents the mesangial cells treated with high-glucose medium and serum from rats treated with SYFSF. HG + I represents the mesangial cells treated with high-glucose medium and serum from rats treated with irbesartan.
