. 2017 Jun 21;2017:8192383. doi: 10.1155/2017/8192383

Table 1.

Characteristics of the 15 included studies.

Study (years)	Species (sex, n = experimental/control group)	Weight	Model (method)	Time drug given	Anesthetic	Treatment group and administration methods	Control group	Angiogenesis outcome index	Intergroup differences (time)	Secondary outcome	Intergroup differences	Side effect
Chao et al. [25]	Male Sprague Dawley rats (8/8)	200–220 g	AMI	1 day after the surgery	Chloral hydrate [0.3 g/kg, (i.p.)]	Salvianolic acid B 24 mg/kg·4 h, i.v.	Normal saline	(1) VEGF	(1) P < 0.001; 8 h	(1) Myocardial infarct size	(1) P < 0.001; 8 h	No report

He et al. [26]	Male Sprague Dawley rats (15/15)	200–220 g	AMI	24 h after the surgery	Urethane [1.2 g/kg, intraperitoneally (i.p.)]	Salvianolic acid B 100 mg/kg·d, i.g.	Normal saline	(1) VEGF	(1) P < 0.05; 4 w	(1) Myocardial infarct size	(1) P < 0.01; 4 w	No report
								(2) BVD	(2) P < 0.05; 4 w	(2) LVSP	(2) P < 0.01; 4 w
										(3) LVEDP	(3) P < 0.01; 4 w
										(4) LVEF	(4) P < 0.05; 4 w

Li et al. [27]	Male Sprague Dawley rats (5/5)	200–220 g	AMI	24 hours after the surgery	3.5% hydrochloride (3.5 mg/100 g, i.p.)	10 mg/kg/d salvianolic acid A i.v.	Normal saline	(1) BVD	(1) P < 0.05; 7 d	(1) Myocardial infarct size	(1) P < 0.01; 1 w	No report
Li et al. [27]	Male Sprague Dawley rats (5/5)	200–220 g	AMI	24 hours after the surgery	3.5% hydrochloride (3.5 mg/100 g, i.p.)	10 mg/kg/d salvianolic acid A i.v.	Normal saline	(2) VEGF	(2) P < 0.001; 7 d	(1) Myocardial infarct size	(1) P < 0.01; 1 w	No report

Yang [28]	Male Sprague Dawley rats (8/8)	180–200 g	AMI	1 week after the surgery	Urethane 1.2 g/kg, i.p.	Salvia extract (salvianolic acid B 20.6%; Danshensu 23.6%; protocatechualdehyde 3.9%) 100 mg/kg/d, i.g.	Normal saline	(1) VEGF	(1) P < 0.05; 60 d	(1) LVSP	(1) P < 0.05; 60 d	No report
								(2) BVD	(2) P < 0.05; 60 d	(2) LVEDP	(2) P < 0.05; 60 d
								(2) BVD	(2) P < 0.05; 60 d	(3) IL	(3) P < 0.05; 60 d

Fang [29]	Male Sprague Dawley rats (13/13)	220–260 g	AMI	3 days after the surgery	10% chloral hydrate (4 ml/kg, i.p.)	Salvianolate (main composition salvianolic acid B) 30 mg/kg·d, i.p.	Normal saline	(1) BVD	(1) P < 0.01; 4 w	No	No	No report
Fang [29]	Male Sprague Dawley rats (13/13)	220–260 g	AMI	3 days after the surgery	10% chloral hydrate (4 ml/kg, i.p.)		Normal saline	(2) VEGF	(2) P < 0.01; 4 w	No	No	No report

Ma [30]	Male Sprague Dawley rats (10/10)	Three months Age	AMI	No report	3% pentobarbital 45 mg/kg, i.p.	Salvianolic acid B 1 g/(kg·d), i.g.	Normal saline	(1) BVD	(1) P < 0.01; 14 d	(1) Myocardial infarct size	(1) P < 0.01; 14 d	No report

Li [31]	Male Sprague Dawley rats (5/5)	200–220 g	AMI	1 day after the surgery	3.5% chloral hydrate (35 g/kg, i.p.)	Salvianolic acid A 10 mg/kg, i.v.	Normal saline	(1) BVD	(1) P < 0.001; 1 w	(1) Myocardial infarct size	(1) P < 0.01; 1 w	No report
								(2) VEGF	(2) P < 0.001; 1 w	(2) SDF-1	(2) P < 0.01; 1 w
								(2) VEGF	(2) P < 0.001; 1 w	(3) MMP-9	(3) P < 0.01; 1 w

Wang [32]	Male piglets (6/6)	28 ± 10 kg	AMI	1 day after the surgery	Ketamine, 20 mg/kg, and diazepam, 0.05 mg/kg, i.m.	Salvianolate (main composition salvianolic acid B) 400 mg, i.v.	Normal saline	(1) BVD	(1) P < 0.01; 4 w	(1) LVEF	(1) P < 0.05; 4 w	No report

Nuan-Liu [33]	Male Sprague Dawley rats (8/8)	200–240 g	AMI	2 days after the surgery	10% chloral hydrate i.p.	Salvia extract (main composition salvianolic acid B) 40 mg/kg·d, i.g.	Normal saline	(1) VEGF	(1) P < 0.01; 4 w	No	No	No report
Nuan-Liu [33]	Male Sprague Dawley rats (8/8)	200–240 g	AMI	2 days after the surgery	10% chloral hydrate i.p.		Normal saline	(2) BVD	(2) P < 0.01; 4 w	No	No	No report

Chen [34]	Male/female Sprague Dawley rats (8/8)	180–220 g	AMI	1 day after the surgery	3% pentobarbital 30 mg/kg i.p.	Salvianolic acid B 6.4 mg, i.v.	Normal saline	(1) VEGF	(1) P < 0.01; 2 w	(1) Myocardial infarct size	(1) P < 0.01; 2 w	No report
								(2) BVD	(2) P < 0.01; 2 w	(2) NO	(2) P < 0.05; 2 w
								(2) BVD	(2) P < 0.01; 2 w	(3) NOS	(3) P < 0.05; 2 w

Fang [35]	Male/female Wistar rats (10/10)	250 ± 50 g	AMI	6 days before the surgery	3% pentobarbital 30 mg/kg, i.p.	Salvianolic acid B 100 mg/(kg·d), i.g.	Normal saline	(1) BVD	(1) P < 0.05; 6 d	(1) Myocardial infarct size	(1) P < 0.01; 6 d	No report
Fang [35]	Male/female Wistar rats (10/10)	250 ± 50 g	AMI	6 days before the surgery	3% pentobarbital 30 mg/kg, i.p.	Salvianolic acid B 100 mg/(kg·d), i.g.	Normal saline	(1) BVD	(1) P < 0.05; 6 d	(2) Fibroblast	(2) P < 0.01; 6 d	No report

Ye [36]	Male Sprague Dawley rats (6/7)	240 ± 60 g	AMI	48 h after the surgery	Ether inhaler	Salvia extract (main composition salvianolic acid B (40 mg/kg·d), i.g.	Normal saline1	(1) VEGF	(1) P < 0.01; 8 w	No	No	No report

Pang [37]	Male Sprague Dawley rats (10/11)	180–220 g	AMI	24 h after the surgery	Ether inhaler	Salvianolic acid B 120 mg/(kg·d) i.g	Normal saline	(1) BVD	(1) P < 0.05; 2 w	(1) Myocardial infarct size	(1) P < 0.05; 2 w	No report
Pang [37]	Male Sprague Dawley rats (10/11)	180–220 g	AMI	24 h after the surgery	Ether inhaler	Salvianolic acid B 120 mg/(kg·d) i.g	Normal saline	(1) BVD	(1) P < 0.05; 2 w	(2) Ventricle thickness	(2) P < 0.05; 2 w	No report

Guo et al. [38]	Female SD rats (no report)	No report	AMI	No report	No report	80 μl of phosphate-buffered saline (PBS) alone and 5 × 10⁶ salvianolic acid B pretreated MSC/d	80 μl of phosphate-buffered saline alone and 5 × 10⁶ MSC/d	(1) BVD	(1) P < 0.01; 4 w	No report	No report	No report
Guo et al. [38]	Female SD rats (no report)	No report	AMI	No report	No report		80 μl of phosphate-buffered saline alone and 5 × 10⁶ MSC/d	(2) VEGF	(2) P < 0.05; 4 w	No report	No report	No report

Note: LAD: the left anterior descending coronary artery; VEGF: vascular endothelium growth factor; LVSP: left ventricular systolic pressure; LVEDP: left ventricular end-diastolic pressure; IL: infarct length; LVEF: left ventricular ejection fraction.