Table 3.

Analysis of prognostic factors influencing overall survival (OS) and disease‐free survival (DFS) in patients with hepatocellular carcinoma

	OS			DFS
	n	χ2‐test	P‐value	n	χ2‐test	P‐value
Age, years
<50	35	3.494	0.062	35	1.502	0.220
≥50	75			75
Gender
Male	98	0.660	0.416	98	0.637	0.425
Female	12			12
Tumor size, cm
<5	52	4.621	0.032*	52	1.304	0.253
≥ 5	58			58
Tumor number
Single	76	11.437	0.001*	76	11.948	0.001*
Multiple	34			34
Satellite lesions
No	59	20.775	<0.001*	59	17.669	<0.001*
Yes	51			51
Portal vein invasion
No	58	12.616	<0.001*	58	14.445	<0.001*
Yes	52			52
Microvascular invasion
No	35	13.368	<0.001*	35	10.825	0.010*
Yes	75			75
Cirrhosis
No	22	2.578	0.108	22	6.321	0.012*
Yes	88			88
Clinal stage
Stage I and II	63	41.424	<0.001*	63	26.147	<0.001*
Stage III and IV	47			47
Histological grade
Well	82	0.535	0.465	82	0.062	0.804
Poor	28			28
HIF‐2α expression
Low expression	60	7.063	0.008*	60	1.998	0.158
High expression	50			50
TGFα expression
Low expression	65	4.294	0.038*	65	0.841	0.359
High expression	45			45
ACSS2 expression
Low expression	56	9.980	0.002*	56	7.048	0.008*
High expression	54			54

HIF‐2α, hypoxia‐inducible factor‐2α; TGFα, transforming growth factor α. *P ≤ 0.05.