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. 2017 Jun 8;108(7):1378–1385. doi: 10.1111/cas.13268

Figure 4.

Figure 4

MET inhibitors induce cell cycle arrest, but not apoptosis, in small‐cell lung cancer cells. (a) SBC‐5, DMS273, and DMS273‐G3H cells were treated with 1 μM crizotinib or golvatinib for 72 h. Cell lysates were then evaluated for protein expression by Western blot analysis. Three independent experiments were carried out, and a representative result is shown. PARP, poly(ADP‐ribose) polymerase. (b) SBC‐5, DMS273, and DMS273‐G3H cells were treated with 1 μM crizotinib or golvatinib for 8 h, and the activity of caspase‐3/7 was then measured using a Caspase‐Glo3/7 assay kit. Error bars represent mean ± SD.