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. 2017 Jun 13;108(7):1493–1503. doi: 10.1111/cas.13267

Figure 4.

Figure 4

Distribution and tumor‐targeted ability of nanoparticles (NPs) and pancreatic cancer hepatic metastases monitored with MRI. (a) Accumulation of targeted and non‐targeted NPs in tumor tissue confirmed using Prussian blue staining of tumor tissue sections. (b) Metastatic nodules in tumor‐bearing mice were imaged by MRI after different treatments with PBS, negative control antisense oligonucleotide and gemcitabine (ASO‐NC‐Gem‐NPs), ASO‐microRNA‐21 (miR‐21)‐NPs, ASO‐miR‐21‐Gem‐NPs combination therapy, or single‐chain variable fragment (ScFv)‐ASO‐miR‐21‐Gem‐NPs. Treatment with ASO‐miR‐21 efficiently reduced pancreatic carcinoma liver metastasis.