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. 2017 Jun 13;108(7):1493–1503. doi: 10.1111/cas.13267

Figure 6.

Figure 6

Histological studies of tumor sections from BALB/c nude mice s.c. inoculated with MIA PaCa‐2 pancreatic cancer cells into the right flank. When the tumor volume had reached approximately 50 mm3, the mice were randomly divided into seven groups, and received different treatments: PBS nanoparticles with negative control antisense oligonucleotide (ASO‐NC‐NPs); ASO‐microRNA‐21 (miR‐21)‐NPs; gemcitabine solution (Gem‐sol); ASO‐NC‐Gem‐NPs; ASO‐miR‐21‐Gem‐NPs; and single‐chain variable fragment (scFv)‐ASO‐miR‐21‐Gem‐NPs. Magnification, ×200 for E‐cadherin and TUNEL; ×100 for other images. *P < 0.05 versus ASO‐miR‐21‐Gem‐NPs; # P < 0.05 versus ASO‐miR‐21‐NPs.