Table 3.
Patients with suspected pathogenic germline variants
Patient | Age | Sex | Tumor type | Family history | Gene | Mutation | Germline testing† |
---|---|---|---|---|---|---|---|
1 | 44 | M | Pancreatic | − | BRCA2 | p.Gln3026* | – |
2 | 78 | F | Colorectal | − | TP53 | p.Arg273His | – |
3 | 57 | M | Colorectal | − | TP53 | p.Gly245Asp | Somatic |
4 | 39 | F | Breast (HBOC) | + | BRCA1 | p.Leu63* | Germline |
5 | 82 | M | Gastric | − | BRCA1 | p.Gln934* | Germline |
TP53 | p.Arg175His | Somatic |
HBOC, hereditary breast and ovarian cancer. †Patients 1 and 2 did not desire to undergo germline testing.