Table 2.
Association between immunohistochemical cytochrome c1 (CYC1) status and clinicopathological parameters in 47 cases of ductal carcinoma in situ
| CYC1 status | P‐value | ||
|---|---|---|---|
| + (n = 19) | − (n = 28) | ||
| Age, years† | 60.3 ± 2.5 | 58.9 ± 1.7 | 0.650 |
| Menopausal status | |||
| Premenopausal | 3 | 6 | |
| Postmenopausal | 16 | 22 | 0.630 |
| Tumor size, cm† | 4.0 ± 0.6 | 2.7 ± 0.3 | 0.048 |
| Nuclear grade | |||
| 1 + 2 | 12 | 25 | |
| 3 | 7 | 3 | 0.032 |
| Comedo necrosis | |||
| Present | 17 | 15 | |
| Absent | 2 | 13 | 0.007 |
| van Nuys classification | |||
| 1 | 0 | 12 | |
| 2 | 12 | 13 | |
| 3 | 7 | 3 | 0.002 |
| ER status | |||
| Positive | 18 | 26 | |
| Negative | 1 | 2 | 0.800 |
| PR LI, %†, ‡ | 49.8 ± 7.4 | 44.0 ± 6.1 | 0.550 |
| HER2 status | |||
| Positive | 10 | 9 | |
| Negative | 9 | 19 | 0.160 |
| Ki‐67 LI, %† | 6.5 ± 0.8 | 4.1 ± 0.6 | 0.011 |
†Data are presented as mean ± SEM. All other values represent the number of cases. ‡Three estrogen receptor (ER)‐negative cases were excluded. Statistical analysis was evaluated by Student's t‐test or a cross‐table using the χ2‐test. P < 0.05 were considered significant (shown in bold). HER2, human epidermal growth factor receptor 2; LI, labeling index; PR, progesterone receptor.