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. 2017 Jul 5;14(7):e1002310. doi: 10.1371/journal.pmed.1002310

Fig 6. Global ischemia/reperfusion study.

Fig 6

Post-reperfusion survival times are shown in (A) for animals treated with ammonium tetrathiomolybdate (ATTM) versus vehicle (control). *p < 0.05, log-rank test, n = 16 per group. Sequential changes in core temperature, heart rate, cardiac output, and blood pressure are shown (B–E). *p < 0.05 using a two-way repeated measures ANOVA plus Bonferroni test. Note that this test was only performed up to 2 h post-reperfusion due to early mortality. Measurements of (F) blood levels of reduced glutathione (GSH; antioxidant reserve capacity), (G) the ratio of GSH to oxidized glutathione (GSSG) (lower values indicate greater oxidative stress), (H) protein carbonyls (oxidative damage), and (I) interleukin-6 (IL-6; systemic inflammation) were performed at 2 h post-reperfusion, before the onset of significant mortality. *p < 0.05, unpaired t-test.