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Guinea pigs were infected on day 0 via inoculation of 1×102, 1×104 or 1×106 IFUs of C. caviae directly into the conjunctival sac (arrow). Pathological signs were followed daily for 21 days post-infection (dashed line). Days 4, 7, 14 and 21 post-infection are chosen as time points when sampling of mucosal washes, sera and swabs were performed, and ex vivo analyses were performed (asterisks).
