Table 2. Summary of literature search.
| Year | First Author | Ethnicity | Cancer Type | Sample Size | Sample | Phenotype | Significant Genes |
|---|---|---|---|---|---|---|---|
| 2015 | den Hoed [36] | C | LL | 134 | Peripheral blood | Mucositis | ABCC4 |
| 2015 | Teo [37] | A | RCC | Blood | Mucositis | ABCB1 | |
| 2015 | Coleman [38] | C | MM | 972 | MIRT bank of germline DNA from leukapheresis products | Mucositis | JPH3, DHRS7C, CEP192, CPEB1/LINC00692, FBN2, ALDH1A1, DMRTA1/FLJ35282 |
| 2014 | Boso [39] | C | Breast cancer | 113 | Blood | Toxicity (mucositis) | ERCC1 |
| 2014 | Venkatesh [14] | C | Head and neck | 183 | Not specified | Acute toxicity (mucositis) > Grade 2 | NBN, XRCC1 |
| 2014 | Liu [40] | A | ALL | 112 | Peripheral blood | Nonhematologic toxicity (mucositis) | ABCC2 |
| 2014 | Ren [13] | C | Nasopharyngeal carcinoma | 120 | Peripheral blood | Severe oral mucositis | XRCC6 |
| 2013 | Yomade [41] | C | ALL | 131 | Peripheral blood | Mucositis | NOD2 |
| 2012 | Dogan [34] | C | Various | 18 (children) | Peripheral blood | Clinical/biochemical toxicity (mucositis) | DPYD, TYMS, MTHFR, XPD, XRCC1 |
| 2012 | Bektas-Kayhan [42] | C | ALL | 47 cases/68 controls | Blood | Mucositis | MDR |
| 2012 | Fidlerova [43] | C | Various | 113 | Blood | Mucositis | UPB1 |
| 2012 | Chen [44] | A | AL | 96 (AL) and 132 (controls) (children) | Bone marrow (AL) Peripheral blood (controls) |
Mucositis | GGH |
| 2012 | Ozdemir [12] | C | Burkitt lymphoma/ALL | 90 (children) | Venous blood | Mucositis | XRCC1 |
| 2012 | Erculj [35] | C | ALL | 167 (children) | Peripheral blood | Mucositis | TYMS |
| 2011 | Thomas [33] | C | Rectal cancer | 131 | Blood | Toxicity (mucositis) | MTHFR |
| 2011 | Pratesi [45] | C | HNSCC | 101 | Peripheral blood | Severe oral mucositis | XRCC1 |
| 2011 | Kotnik [46] | C | ALL/lymphoma | 64 (children) | Peripheral blood | Mucositis | TYMS |
| 2010 | Banklau [47] | A | ALL/LL | 94 | Peripheral blood | Mucositis | DCK |
| 2010 | Cho [48] | A | Large B cell lymphoma | 94 | Peripheral blood | Mucositis | GSTT1 |
| 2010 | Dumontet [49] | C | MM | 169 | Peripheral blood | Severe mucositis | BRCA1, CDKN1A, XRCC1 |
| 2010 | Tantawy [50] | C | LL | 40 | Peripheral blood | Mucositis/mucosal toxicity | MTHFR |
| 2010 | Fidlerova [51] | C | Various | 113 | Blood | Mucositis | DPYS |
| 2009 | van Erp [52] | C | Various | 219 | Blood or serum | Mucosal inflammation | CYP1A1 |
| 2009 | Kleibl [53] | C | Colorectal | 76 | Blood | Mucositis | DPYD |
| 2009 | Rocha [32] | C | Leukemia | 107 patients/ 107 donors | Peripheral blood | Mucositis | CYP2B6 |
| 2008 | Schwab [54] | C | Various | 683 | Peripheral blood | Toxicity (severe leukopenia, diarrhea and mucositis) | DPYD |
| 2007 | Gemmati [55] | C | NHL | 110 | Peripheral blood | Mucositis | MTHFR |
| 2006 | Robien [56] | C | CML | 172 | Not specified | Mucositis | MTHFR |
| 2001 | Ulrich [57] | C | CML | 220 | Not specified | Mucositis (oral mucositis index) | MTHFR |
Ethnicity: C, Caucasian; A, Asian. Cancer type: LL, lymphoblastic lymphoma; RCC, renal cell carcinoma; MM, multiple myeloma; AL, acute leukemia; ALL, acute lymphoblastic leukemia; HNSCC, squamous cell carcinoma of the head and neck; NHL, non-Hodgkin lymphoma; CML, chronic myeloid leukemia.