Table 3. Molecules with ≥ 15 connections (hubs*) and focus genes with < 15 connections in the network, ranked by number of connections.
| IPA symbol | Focus gene | Molecule type | Number of connections |
|---|---|---|---|
| TP53 | No | transcription regulator | 88 |
| CDKN1A | Yes | kinase | 51 |
| CTNNB1 | No | transcription regulator | 39 |
| MYC | No | transcription regulator | 36 |
| RB1 | No | transcription regulator | 26 |
| P38 MAPK | No | group | 22 |
| BRCA1 | Yes | transcription regulator | 20 |
| EP300 | No | transcription regulator | 16 |
| NBN | Yes | other | 6 |
| XRCC6 | Yes | enzyme | 6 |
| CYP2B6 | Yes | enzyme | 5 |
| NOD2 | Yes | other | 4 |
| CYP1A1 | Yes | enzyme | 3 |
| TYMS | Yes | enzyme | 3 |
| ABCC2 | Yes | transporter | 2 |
| ERCC1 | Yes | enzyme | 2 |
| ABCB1 | Yes | transporter | 1 |
| ALDH1A1 | Yes | enzyme | 1 |
| CPEB1 | Yes | translation regulator | 1 |
| MTHFR | Yes | enzyme | 1 |
* Suggests biological importance