Table 4. Top canonical pathways (B-H p-valueƗ < 10−5) discovered by IPA core analysis*.
| Ingenuity Canonical Pathways | p-value | B-H p-value |
# of molecules in pathway | # of focus genes | Ratioǂ |
|---|---|---|---|---|---|
| Uracil Degradation II (Reductive) | 1.06E-08 | 4.02E-07 | 4 | 3 | 75% |
| Thymine Degradation | 1.06E-08 | 4.02E-07 | 4 | 3 | 75% |
| LPS/IL-1 Mediated Inhibition of RXR Function | 4.18E-07 | 1.06E-05 | 208 | 6 | 3% |
| DNA Double-Strand Break Repair by Non-Homologous End Joining | 9.53E-07 | 1.81E-05 | 14 | 3 | 21% |
| Xenobiotic Metabolism Signaling | 1.40E-06 | 2.14E-05 | 256 | 6 | 2% |
| PXR/RXR Activation | 1.90E-06 | 2.41E-05 | 63 | 4 | 6% |
* Ranked by B-H p-value.
Ɨ Benjamini-Hochberg multiple testing correction p-value.
ǂ Ratios are calculated by taking the number of focus genes that are included in the canonical pathway divided by the number of the molecules that make up the canonical pathway.