Table 6. Results of the genetic association analysis for oral mucositis in 885 head and neck cancer patients (186 oral mucositis cases and 699 controls), using the IPA-derived hubs (most interconnected molecules) as the candidate molecules.
| IPA SymbolƗ | Location | Type | # of SNPs | Genes | Chr | rs# | OR [95% CI] |
p-valueǂ |
|---|---|---|---|---|---|---|---|---|
| TP53 | Nucleus | transcription regulator | 4 | TP53 | 17 | rs1625895 | 1.17 [0.83, 1.64] | 0.380 |
| CDKN1A** | Nucleus | kinase | 3 | CDKN1A | 6 | rs3176331 | 1.11 [0.79, 1.57] | 0.545 |
| CTNNB1 | Nucleus | transcription regulator | 4 | CTNNB1 | 3 | rs3915129 | 1.03 [0.81, 1.30] | 0.805 |
| MYC* | Nucleus | transcription regulator | 0 | MYC | 8 | - | - | - |
| RB1 | Nucleus | transcription regulator | 6 | RB1 | 13 | rs2227311 | 0.67 [0.46, 0.97] | 0.034 |
| P38 MAPK | Cytoplasm | Group | 31 | MAPK11 | 22 | rs742186 | 0.84 [0.67, 1.06] | 0.150 |
| BRCA1** | Nucleus | transcription regulator | 13 | BRCA1 | 17 | rs799917 | 0.80 [0.63, 1.03] | 0.086 |
| EP300 | Nucleus | transcription regulator | 5 | EP300 | 22 | rs2294976 | 1.29 [0.85, 1.94] | 0.230 |
Ɨ IPA symbol represents either a gene or a group of genes.
ǂ The most significant p-value for a gene or a gene group.
* The genotyping chip does not have SNPs in this gene.
** Focus genes.
CI Confidence interval.