Table 2.
Genetic Counselor (GC) compared with Health History Questionnaire (HHQ) assessment of family history by cancer type and relative degree for the 61 patients in Prevention Program.
Wilcoxon Signed Rank-Sum | Generalized Linear Mixed Models | ||||
---|---|---|---|---|---|
| |||||
Cancer Type | GC | HHQ | p-value | i(β) | p-value |
First Degree Relative | |||||
Total Relatives Documented | 333 | 339 | 0.47 | 0.02 | 0.82 |
Pancreas | 50 | 52 | 0.50 | 0.00 | >0.99 |
Breast | 12 | 12 | >0.99 | 0.00 | >0.99 |
Ovarian | 5 | 4 | >0.99 | −0.22 | 0.74 |
Prostate | 6 | 5 | >0.99 | −0.18 | 0.76 |
Colorectal | 1 | 1 | N/A# | N/A# | N/A# |
Other | 21 | 22 | >0.99 | 0.11 | 0.68 |
No Cancer | 228 | 238 | 0.55 | 0.04 | 0.64 |
Second Degree Relative | |||||
Total Relatives Documented | 847 | 581 | <0.0001@ | −0.38 | <0.001@ |
Pancreas | 21 | 22 | >0.99 | 0.03 | 0.90 |
Breast | 18 | 18 | >0.99 | −0.04 | 0.89 |
Ovarian | 8 | 5 | 0.45 | 0.00 | >0.99 |
Prostate | 8 | 9 | >0.99 | 0.12 | 0.81 |
Colorectal | 11 | 11 | >0.99 | −0.08 | 0.84 |
Other | 34 | 32 | 0.73 | 0.14 | 0.46 |
No Cancer | 710 | 446 | <0.0001@ | −0.46 | <0.001@ |
Third Degree Relative | |||||
Total Relatives Documented | 828 | 122 | <.0001@ | −1.61 | <0.001@ |
Pancreas | 8 | 3 | 0.50 | −0.81 | 0.18 |
Breast | 9 | 9 | >0.99 | −0.24 | 0.55 |
Ovarian | 2 | 2 | >0.99 | 0.00 | >0.99 |
Prostate | 2 | 3 | >0.99 | −0.51 | 0.49 |
Colorectal | 9 | 3 | 0.13 | −0.92 | 0.13 |
Other | 15 | 14 | >.99 | 0.23 | 0.45 |
No Cancer | 766 | 71 | <0.0001@ | −2.04 | <0.001@ |
Significant values were reported, due to the observation that GCs typically document more second- and third-degree relatives compared with HHQ.
Unable to assess