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In vivo Pharmacokinetic Parameters in Calves after P.O. Administration of 10 mg/kg BKIs 1294, 1553, and 1517
| Compound | Tmax (hr) | Cmax (μM) | AUC (μM*hr) | t1/2 (hrs) | Oral Clearance (mL/min/kg) | Fecal Concentration (μM) |
|---|---|---|---|---|---|---|
| BKI-1294 | 2 | 2.3 | 48 | 26 | 8.4 | 0.4 |
| BKI-1553 | 12 | 7.9 | 596 | 23 | 0.7 | 1.2 |
| BKI-1517 | 4 | 1.5 | 21 | 14 | 22.4 | 4.2 |
