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. Author manuscript; available in PMC: 2017 Jul 6.
Published in final edited form as: Mol Pharm. 2017 Mar 2;14(4):999–1011. doi: 10.1021/acs.molpharmaceut.6b00770

Figure 4.

Figure 4

P-glycoprotein is upregulated in isolated brain capillaries from chronic epileptic rats. (A) Schematic showing the protocol to generate chronic epileptic rats using the fractionated pilocarpine dose approach. (B) Western blot and (C) transport activity assay showing that P-gp protein expression and transport activity levels are increased in brain capillaries isolated from CE rats. Data are mean ± SEM (n = 10–15 capillaries per treatment group; pooled tissue from all rats per group; control group n = 10 rats, chronic epileptic group n = 5 rats). Units are arbitrary fluorescence units (scale, 0–255). Statistical comparison (one-way ANOVA): ***, significantly higher than controls, p < 0.001.