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. 2017 Jul 6;8:442. doi: 10.3389/fphar.2017.00442

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Copyright © 2017 Shenoy, Kuo, Vetter and Smith.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Paw withdrawal thresholds (PWTs) of ipsilateral and contralateral hindpaws of rats. Panels in the figure show mean (±SEM) PWTs of rats from (A) experiment 2, (B) experiment 3 and (C) experiment 5. Rats with PWTs ≤6 g in the ipsilateral hindpaw were considered to have fully developed mechanical allodynia as indicated by the dotted line. HK, heat-killed; W256, Walker 256. ^∗p ≤ 0.05 (Two-way ANOVA, post hoc Bonferroni test) c.f. rats given an ITI of HK W256 cells.