Table 2.
Extent and duration of anti-allodynia (ΔPWT AUC) and potencies of test compounds.
| ED50 for the alleviation of mechanical allodynia in the bilateral hindpaws (mg/kg) |
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|---|---|---|---|---|---|---|---|---|---|---|
| Time (h) |
Mean ΔPWT at peak effect (g) |
ΔPWT AUC (g.h) |
Ipsilateral |
Contralateral |
||||||
| Test compound and route of administration | Peak effect | ~Duration of action | Ipsi | Contra | Ipsi | Contra | Mean | 95% CI | Mean | 95% CI |
| Morphine (s.c.) | ||||||||||
| 0.3 mg/kg | 0.5–0.75 | 2 | 1.9 (±0.76) | 2.2 (±1.07) | 3.7 (±0.88) | 3.9 (±1.28) | 1.3 | 0.90–1.83 | 1.4 | 0.98–2.08 |
| 1 mg/kg | 4.1 (±0.70) | 4.2 (±0.72) | 4.7 (±0.38)∗ | 4.8 (±0.49)∗ | ||||||
| 3 mg/kg | 6.9 (±1.00) | 6.2 (±0.72) | 9.6 (±1.22)∗ | 10.2 (±1.28)∗ | ||||||
| Vehicle | NA | NA | 1.8 (±0.44) | 2.2 (±0.38) | ||||||
| Gabapentin (i.p.) | ||||||||||
| 30 mg/kg | 1.25–1.5 | >3 | 2.6 (±0.83) | 2.4 (±0.78) | 4.5 (±0.73) | 4.5 (±0.61) | 47.1 | 35.25–63.04 | 30.8 | 21.9–43.2 |
| 70 mg/kg | 3.7 (±0.61) | 3.7 (±0.68) | 6.8 (±0.46)∗ | 7.5 (±0.63)∗ | ||||||
| 100 mg/kg | 4.1 (±0.70) | 4.1 (±0.58) | 8.4 (±1.08)∗ | 8.3 (±0.83)∗ | ||||||
| Vehicle | NA | NA | 2.0 (±0.43) | 3.0 (±0.76) | ||||||
| Amitriptyline (i.p.) | ||||||||||
| 3 mg/kg | 0.75–1.25 | 2 | 2 (±0.81) | 2.1 (±0.78) | 2.6 (±0.80) | 2.6 (±0.75) | 20.1 | 13.82–29.11 | 21.4 | 14.27–32.19 |
| 10 mg/kg | 3.3 (±0.99) | 2.8 (±0.78) | 4.5 (±0.89) | 4.0 (±0.99) | ||||||
| 30 mg/kg | 5.8 (±1.15) | 4.9 (±0.89) | 7.8 (±1.28)∗ | 7.4 (±1.42)∗ | ||||||
| Vehicle | NA | NA | 1.4 (±0.45) | 1.7 (±0.27) | ||||||
| Meloxicam (i.p.) | ||||||||||
| 2.5 mg/kg | 1.25–1.5 | >3 | 2.6 (±0.83) | 2.2 (±0.66) | 4.5 (±0.67)∗ | 4.5 (±0.65)∗ | 3.9 | 2.79–5.43 | 3.5 | 2.51–4.79 |
| 5 mg/kg | 4.3 (±0.45) | 4.3 (±0.45) | 8.1 (±1.07)∗ | 8.2 (±1.00)∗ | ||||||
| 7.5 mg/kg | 6.1 (±0.96) | 5.3 (±0.62) | 11.5 (±1.22)∗ | 10.3 (±1.04)∗ | ||||||
| Vehicle | NA | NA | 1.8 (±0.64) | 2.0 (±0.68) | ||||||
CI, confidence interval; Contra., contralateral hindpaws; Ipsi., ipsilateral hindpaws; NA, not applicable; ∗p ≤ 0.05 (One-way ANOVA, post hoc Dunnett’s multiple comparisons test) c.f. rats that received single bolus doses of vehicle.