Table 3.
Time (h) |
Mean ΔPPT at peak effect (g) |
ΔPPT AUC (g.h) |
||||
---|---|---|---|---|---|---|
Test compound and route of administration | Peak effect | ~Duration of action | Ipsilateral | Contralateral | Ipsilateral | Contralateral |
Morphine (s.c.) | ||||||
3 mg/kg | 0.5 | 2 | 40 (±11.62) | 36.7 (±10.88) | 49.5 (±17.28)∗ | 46.7 (±17.21)∗ |
Vehicle | NA | NA | 10.0 (±4.18) | 9.2 (±4.85) | ||
Gabapentin (i.p.) | ||||||
100 mg/kg | 1.25 | >3 | 32.5 (±10.7) | 30.8 (±10.60) | 64.2 (±19.79) | 61.8 (±18.71) |
Vehicle | NA | NA | 9.7 (±3.48) | 5.4 (±3.35) | ||
Amitriptyline (i.p.) | ||||||
30 mg/kg | 0.75 | 2 | 38.9 (±14.55) | 36.7 (±13.42) | 54.7 (±17.69) | 53.3 (±17.30) |
Vehicle | NA | NA | 11.6 (±2.36) | 10.5 (±3.69) | ||
Meloxicam (i.p.) | ||||||
7.5 mg/kg | 1.25–1.5 | >3 | 41.7 (±14.64) | 38.6 (±13.22) | 85.0 (±33.62) | 82.0 (±32.52) |
Vehicle | NA | NA | 8.1 (±4.69) | 4.1 (±4.06) |
NA, not applicable; ∗p ≤ 0.05 (Mann–Whitney test) c.f. rats that received single bolus doses of vehicle.