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. 2017 Jul 6;8:442. doi: 10.3389/fphar.2017.00442

Table 3.

Extent and duration of anti-hyperalgesia (ΔPPT AUC).

Time (h)
Mean ΔPPT at peak effect (g)
ΔPPT AUC (g.h)
Test compound and route of administration Peak effect ~Duration of action Ipsilateral Contralateral Ipsilateral Contralateral
Morphine (s.c.)
3 mg/kg 0.5 2 40 (±11.62) 36.7 (±10.88) 49.5 (±17.28) 46.7 (±17.21)
Vehicle NA NA 10.0 (±4.18) 9.2 (±4.85)
Gabapentin (i.p.)
100 mg/kg 1.25 >3 32.5 (±10.7) 30.8 (±10.60) 64.2 (±19.79) 61.8 (±18.71)
Vehicle NA NA 9.7 (±3.48) 5.4 (±3.35)
Amitriptyline (i.p.)
30 mg/kg 0.75 2 38.9 (±14.55) 36.7 (±13.42) 54.7 (±17.69) 53.3 (±17.30)
Vehicle NA NA 11.6 (±2.36) 10.5 (±3.69)
Meloxicam (i.p.)
7.5 mg/kg 1.25–1.5 >3 41.7 (±14.64) 38.6 (±13.22) 85.0 (±33.62) 82.0 (±32.52)
Vehicle NA NA 8.1 (±4.69) 4.1 (±4.06)

NA, not applicable; p ≤ 0.05 (Mann–Whitney test) c.f. rats that received single bolus doses of vehicle.