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Effects of MK2206-mediated Akt inhibition on the beneficial effects of TUDCA on oedema at 72 h after TBI. Brain water content was detected at 72 h after TBI. However, this protective effect of TUDCA was reversed by MK2206 administration. All the results are expressed as the mean ± SEM, and n = 5 for each group. *p < 0.05 vs. sham; #p < 0.05 vs. control; &p < 0.05 vs. TUDCA.
