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Effects of TUDCA on the PERK-ATF4-CHOP signaling pathway, the Bcl-2/Bax ratio and the expression level of Caspase-12 at 72 h after TBI. Representative results of p-PERK/PERK (A), p-eIF2α/ eIF2α (B), Bcl-2/Bax (C), ATF4 (D), Caspase-12 (E) and CHOP (F) alterations in the different groups. β-actin was used as the loading control. All the results are expressed as the mean ± SEM, and n = 5 for each group. *p < 0.05 vs. sham; #p < 0.05 vs. control.
