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. 2017 Jul 5;7:4739. doi: 10.1038/s41598-017-04972-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of morphine and pregabalin on CNO-induced spontaneous nocifensive behaviours. (a,b) Effects of morphine (3 mg kg⁻¹, s.c.) on CNO-induced nocifensive behaviours (left, licking and biting; right, flinching) ((a) n = 5; *P < 0.05, **P < 0.01, ***P < 0.001 vs. CNO + saline) and on c-Fos⁺ cells in the SDH. c-Fos immunoreactivity in the SDH (b) and quantification ((c) n = 5). (d–f) Effects of intrathecal administration of pregabalin (10 μg/5 μL) on CNO-induced nocifensive behaviours (left, licking and biting; right, flinching) ((d) n = 6–7; *P < 0.05, **P < 0.01 vs. CNO + PBS) and on c-Fos⁺ cells in the SDH. c-Fos immunoreactivity in the SDH (e) and quantification ((f) n = 7; **P < 0.01). Data are means ± SEM.