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. 2017 Jul 5;7:4679. doi: 10.1038/s41598-017-04889-x

Figure 6.

Figure 6

Binding and neutralizing antibody responses in guinea pigs infected with GTOV. (A) Antibody binding titers were determined by coating 96-well plates with the indicated PsVs and incubating them with serially diluted antiserum samples from before (circles/PRE) or after (squares/POST) challenge with GTOV. The dashed line denotes the limit of detection. The red circle denotes the single animal (Animal #4) that succumbed to infection. The blue symbols denote the same animal before and after GTOV challenge. Note that titers against MACV prior to GTOV challenge are also depicted in Fig. 4B. (B) PRNT80 titers against MACV (Car68) prior to and after challenge with GTOV were determined as above. Note that PRNT80 titers prior to GTOV challenge are also depicted in Fig. 4C. (C) PRNT50 titers against JUNV, MACV and GTOV were determined as in Fig. 2. Titers were determined as described above. The dashed line indicates the limit of detection. For all panels, asterisks denote statistical significance.