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. 2017 Jul 5;7:4718. doi: 10.1038/s41598-017-05088-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Additional deletions observed in LdCen ^−/− mutant in Chromosomes 10. (A) The deletions predicted by the bioinformatics analysis are shown as red bars. The gene arrangement in the reference L. donovani genome (as yet fully annotated) is shown as a black bar. The open reading frames are shown as green bars and the untranslated regions (UTR) are shown as blue bars. The size of the deletion is also indicated. Five copies of folate/biopterin transporter and gp63 genes are shown. The sixth folate/biopterin transporter gene located upstream of the five copies on chromosome 10 is not shown (corresponding to LinJ.10.0360). (B) Sequence coverage maps for the three tandem folate/biopterin genes are shown. (C) The deletions predicted in the gp63 region are shown as red bars. The gene arrangement in the reference L. infantum genome is shown as a black bar. (D) Sequence coverage of five gp63 genes on chromosome 10 is shown. (E) Sequence coverage of gp63 ORFs based on L infantum genome is shown. The yellow highlighted regions represent lack of coverage in LdCen ^−/− genome. The location identifiers for each of the genes are shown.