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. 2017 Jul 5;7:4657. doi: 10.1038/s41598-017-04730-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Role of FFAR1 in the effect of palmitate on human islet respiration. OCR recordings from human islets exposed to 5.6 mM glucose (white symbols) and 0.5 mM palmitate (black symbols) and sequential addition of ANT203 (panel A). Difference in OCR 20 minutes prior and post addition of ANT203 (panel B). OCR recordings from human islets exposed for 2 hours to 5.6 mM glucose (white symbols), 0.5 mM palmitate (black circles, black bars) or palmitate with ANT825 (black triangles, black bars) and the sequential addition of oligomycin and rotenone/antimycin (panel C). Mitochondrial respiration (panel D) and ATP-coupled respiration (panel E) are shown. Results show mean ± SD in (panels A−C) (N = 10) and mean ± SEM in (panels D and E) (n = 5–7 donor experiments). *P < 0.05 vs. control and ^#p < 0.05 vs. palmitate.