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. 2017 Jul 5;7:4653. doi: 10.1038/s41598-017-04748-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Competition experiments with compounds I-20 and I-42 and labeled DNA. Each gel depicts the alleviation of inhibition exhibited by compound I-20 (a) and compound I-42 (b) in the presence of increasing DNA. Lanes 1, 8, 15- free DNA (0.8 pmoles), lanes 2,9,16- IdeR+DNA (0.8 pmoles)+DMSO (vehicle control), lanes 3, 10, 17- IdeR+DNA (0.8 pmoles)+ inhibitor, lanes 4, 11, 18 - IdeR+ DNA (1.6 pmoles)+ inhibitor, lanes 5, 12, 19 - IdeR+DNA (3.2 pmoles)+ inhibitor, lanes 6, 13, 20 - IdeR+DNA (6.4 pmoles)+ inhibitor, lanes 7, 14, 21 - IdeR+DNA (12.8 pmoles)+ inhibitor. The bar diagram represents the percent bound DNA at varying DNA concentrations (x represents 0.8 pmoles of labeled DNA, dotted lines represent separate gels). The data is represented as Mean ± S.E.M by values obtained from two independent experiments.