Table 1.
Inhibitors exhibiting whole cell M. tuberculosis broth inhibition and cytotoxicity studies.
| Compound No. | NSC ID | MIC90 of compounds against M. tuberculosis (µg/ml) | Inhibition in THP1 (IC50 in µg/ml) | Inhibition in HEK (IC50 in µg/ml) | Inhibition in MDCK (IC50 in µg/ml) | Inhibition in HepG2 (IC50 in µg/ml) |
|---|---|---|---|---|---|---|
| I-33 | 662443 | 93.3 ± 8.16 | >200 | >200 | >200 | >200 |
| I-34 | 662444 | 86.6 ± 7.8 | >200 | >200 | >200 | >200 |
| I-108 | 282699 | 17.5 ± 3.06 | 167.5 ± 5.6 | >200 | >200 | >200 |
| IS-4 | 33755 | 100 | 165.8 ± 3.72 | 164.7 ± 1.24 | 172.8 ± 2.3 | 176.3 ± 1.6 |
| IS-54 | 34445 | 84.8 ± 8 | 181.6 ± 5.2 | 161.1 ± 4.22 | 174.3 ± 6.4 | 167.4 ± 3.78 |
| Rifampicin | 0.05–0.2 | >100 | >100 | >100 | >100 |