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. 2017 Mar 7;34(8):1658–1672. doi: 10.1007/s11095-017-2130-6

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Spatial context of promoters containing VPA pharmacogenomic SNPs. (a) Whole genome plot of transcriptional hub based on cis- and trans-contacts of the SNP rs3764028_G in the promoter of the GRIN2B gene based on data from Hi-C mapping of this SNP in the human neuronal cell line SK-N-SH. (b) Relative location of the VPA pharmacogenomic SNP rs2269577 (green line), with histone marks H3K27ac and H3K4me4 indicative of an active promoter, location in a DNase I hypersensitivity region indicative of open chromatin, and overlapping a HOT domain containing many TFs (39). This SNP is located within a TAD located on chromosome 22 (26,600,000–28,000,000) (46) containing the XBP1 gene as well as other genes. Inset. Screenshots from the UCSC genome browser, build hg18, taken from the UCSC genome browser in (b) (47).