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. 2017 Jul 5;7:4637. doi: 10.1038/s41598-017-04113-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miR-145 negatively regulates invasion, migration and EMT phenotype of HCC cells. (A) qRT-PCR detection of miR-145 expression in miR-145/inhibitor transfected HepG2 or SMMC-7721 cells and miR-145/mimics transfected HCCLM3 or MHCC97-H cells. (B) Wound healing assay, and (C) transwell assays on HepG2 cells transfected with miR-145/inhibitor (or miR-NC/inhibitor) and HCCLM3 cells transfected with miR-145/mimics (or miR-NC/mimics), respectively. (D) Western blotting and (E) immunofluorescence analysis of changes in epithelial and mesenchymal markers of miR-145/inhibitor transfected HepG2 cells and miR-145/mimics transfected HCCLM3 cells. Each experiment was performed at least three times. *p < 0.05; **p < 0.01.