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. 2017 Jul 5;7:4637. doi: 10.1038/s41598-017-04113-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Linc-ROR acts as a ceRNA for ZEB2 by releasing miR-145 in HCC cells. (A) qRT-PCR and Western blotting assays were performed to detect the mRNA and protein levels of ZEB2 after cells transfected with linc-ROR and miR-145/mimics. **p < 0.01 vs. Vector group; ^##p < 0.01 vs. linc-ROR + miR-NC/mimics group. (B) qRT-PCR and Western blotting assays were performed to detect the mRNA and protein levels of ZEB2 after cells transfected with shROR and miR-145/inhibitor. **p < 0.01 vs. shCtrl group; ^##p < 0.01 vs. shROR + miR-NC/inhibitor group. (C) qRT-PCR detection of miR-145 expression in HCC and adjacent nontumor liver tissues (p < 0.01), showing negative correlation between linc-ROR and miR-145 expression levels in HCC tissues (Spearman’s correlation, r = −0.716, p < 0.01). (D) The expression of ZEB2 in paired samples of primary HCC and adjacent nontumor liver tissues, showing positive correlation between ROR expression and ZEB2 expression in HCC tissues (Spearman’s correlation, r = 0.804, p < 0.01). (E) Schematic overview of linc-ROR regulatory signaling. T: HCC tissues; N: nontumor liver tissues. Data are presented as mean ± SD from three independent experiments. ***p < 0.001.