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. 2017 Apr 10;34(8):1584–1600. doi: 10.1007/s11095-017-2153-z

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Structures of the physiologically-based pharmacokinetic (PBPK) model of irinotecan and its metabolites. (a) shows a module of PBPK model. The liver compartment was adapted as a permeability-limited model and divided into five compartments (23) to construct a model similar to the dispersion model. Enterohepatic circulation was considered. Permeability between the intestinal lumen and enterocytes and between enterocytes and mucosal blood was also incorporated. Portal vein blood flow was divided into mucosal blood flow (Q_mucosa) and serosal blood flow (Q_serosa). (b) Each module for irinotecan and the metabolites is connected shown here based on the scheme in Fig. 1.