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. 2017 Apr 10;34(8):1584–1600. doi: 10.1007/s11095-017-2153-z

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — The association between the UGT1A1 *28 or SLCO1B1 c.521T>C polymorphism and dose-normalized SN-38 plasma concentration at the end of infusion (90 min) with 9 VCSs of 100 times of VCSs. (a) and (a) show the association between the UGT1A1 *28 polymorphism and dose-normalized SN-38 plasma concentration. (c) and (d) show the association between the SLCO1B1 c.521T>C polymorphism and dose-normalized SN-38 plasma concentration. In (a) and (c), each virtual patient was generated from the set of parameters ID 1. In (b) and (d), each virtual patient was generated from the set of parameters ID 5. The top-left panel in each figure shows the results of the target study (20). The others show 9 of the 100 times of VCSs. * p < 0.05, ** p < 0.01, *** p < 0.01.

Fig. 5 — The association between the UGT1A1 *28 or SLCO1B1 c.521T>C polymorphism and dose-normalized SN-38 plasma concentration at the end of infusion (90 min) with 9 VCSs of 100 times of VCSs. (a) and (a) show the association between the UGT1A1 *28 polymorphism and dose-normalized SN-38 plasma concentration. (c) and (d) show the association between the SLCO1B1 c.521T>C polymorphism and dose-normalized SN-38 plasma concentration. In (a) and (c), each virtual patient was generated from the set of parameters ID 1. In (b) and (d), each virtual patient was generated from the set of parameters ID 5. The top-left panel in each figure shows the results of the target study (20). The others show 9 of the 100 times of VCSs. * p < 0.05, ** p < 0.01, *** p < 0.01.