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. 2017 Apr 10;34(8):1584–1600. doi: 10.1007/s11095-017-2153-z

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — The association between the number of virtual patient and the reproduction frequency of the effect of UGT1A1 *28 or SLCO1B1 c.521T>C polymorphism on dose-normalized SN-38 plasma concentration at the end of infusion (90 min) among 100 times of VCSs. The reproduction frequency of (a) shows the effect of UGT1A1 *28 polymorphism on dose-normalized SN-38 plasma concentration. The reproduction frequency of (b) shows the effect of SLCO1B1 c.521T>C polymorphism on dose-normalized SN-38 plasma concentration. The set of parameters ID 1 (×) and 5 (○) were used. The number of virtual population in X-axis is shown as a logarithmic scale.