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. 2017 Apr 10;34(8):1584–1600. doi: 10.1007/s11095-017-2153-z

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 7 — Comparison between clinical study and virtual clinical study outcomes using 9 different sets of parameters determined by CNM. (a) and (b) show the association between dose-normalized SN-38 plasma concentrations at the end of infusion (90 min) and the UGT1A1*28 genotype (a) and SLCO1B1 c.521T>C genotype (b). The top-left panel in each figure shows the results of the target study (20). The others show 9 sets of parameters of the 30 sets optimized by CNM. * p < 0.05, ** p < 0.01, *** p < 0.01.