FIG 4.

Reduced C3 deposition on S. Typhimurium during the acute phase of P. falciparum infection in children. Serum (n = 10) was randomly selected from donor children >24 months of age during malaria and from controls. (A) Serum bactericidal activity was reported as the log10 change in S. Typhimurium CFU counts per milliliter from the baseline, and this was plotted as indicated during malaria and in controls. (B) Serum bactericidal activity and malaria were linked. (D and F) The proportions of C3 deposition (D) and C5b-9 deposition (F) on S. Typhimurium measurements for each subject during current and convalescent malaria are linked by solid gray lines. Red bars represent the median, and statistical differences were determined by the Wilcoxon signed-rank test and Mann-Whitney U test.