Figure 2.

Tumour antigen uptake and presentation by dendritic cells recruits cytotoxic CD8+ T lymphocytes. Tumour cells display tumour antigens at a high density, facilitating cross‐linking of IgE fixed to FcεRI receptors on antigen‐presenting cells, such as dendritic cells (DCs). Tumour antigens may be taken up via three possible routes: (1) soluble tumour antigen binding to receptor‐bound IgE; (2) By IgE‐opsonized soluble antigen binding to IgE receptors and (3) IgE‐opsonized tumour cells binding to IgE receptors. Endocytosis of IgE–antigen complexes leads to digestion in lysosomes and loading of antigenic peptides on MHC I molecules. Cross‐presentation via proteasome, loading to MHC I and recognition by CD8+ T lymphocytes (CTLs) is depicted.