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. 2017 Jan 23;72(6):866–887. doi: 10.1111/all.13119

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© 2016 The Authors. Allergy Published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Treating hypersensitivity in clinical oncology. (A) Proposed algorithm for the evaluation of hypersensitivity of chemotherapy drugs and indications for rapid drug desensitization (RDD). BAT, basophil activation test; HSR, immediate hypersensitivity reaction. (B) Proposed mechanism for chemotherapy RDD (adapted from Ref. 164). (C) Outcomes of Brigham and Women's Hospital desensitization protocols for carboplatin, paclitaxel and rituximab in 2177 cases for 370 patients (adapted from Ref. 133).