Table 3.

Cross‐reactivity of IgE and Fcε receptors of different species, with the equilibrium association constant (K _A) or equilibrium dissociation constant (K _D), where available, described exactly as in the original references

Species	Human FcεRI	NHP* FcεRI	Mouse FcεRI	Rat FcεRI	Dog FcεRI
Human IgE	K A a = 0.5–2.7 × 109 M−1 Ishizaka T, Soto CS, Ishizaka K. Mechanisms of passive sensitization. III. J Immunol 1973; 111(2):500–11 Pruzansky JJ, Patterson R. Immunology 1986; 58(2):257–62	K D a = 1.876 × 10−8 M Saul L et al. MAbs 2014; 6(2):509–22	No binding Fung‐Leung WP et al. J Exp Med 1996;183:49–56	No binding Fung‐Leung WP et al. J Exp Med 1996;183:49–56	No binding Lowenthal M, Patterson R, Harris KE. Ann Allergy 1993; 71(5):481–4
NHP IgE	K D = 3 × 10−10 M Meng YG, Singh N, Wong WL. Mol Immunol 1996; 33(7–8):635–42	N.D.	N.D.	N.D.	No binding Lowenthal M, Patterson R, Harris KE. Ann Allergy 1993; 71(5):481–4
Mouse IgE	K A a = 4.4 × 108 M−1	N.D.	K A a = 1.75–3.57b × 109 M−1 Sterk AR, Ishizaka T. J Immunol 1982; 128(2):838–43	K A a = 2.49–5.05c × 109 M−1 Sterk AR, Ishizaka T. J Immunol 1982; 128(2):838–43	N.D.
Rat IgE	K D a = 1.58 × 10−8 M Mallamaci MA et al. J Biol Chem 1993; 268(29):22076–83	N.D.	K A a = 1.46–2.68b × 109 M−1 Sterk AR, Ishizaka T. J Immunol 1982; 128(2):838–43	K A a = 7.84–8.05c × 109 M−1 Sterk AR, Ishizaka T. J Immunol 1982; 128(2):838–43	N.D.
Dog IgE	K D = 9.2 × 10−9 M Fung‐Leung WP et al. J Exp Med 1996;183:49–56 Ye H et al. Mol Immunol 2014; 57(2):151–9	Confirmed binding Fung‐Leung WP et al. J Exp Med 1996;183:49–56	N.D.	N.D.	K D = 2.1 × 10−8 M Ye H et al. Mol Immunol 2014; 57(2):151–9

N.D., not determined; NHP, non‐human primates.

^aAffinity determination based on cells, not receptor subunits; therefore, also CD23 binding might contribute to the denoted values.

^bDepending on mouse strain used as a source of mast cells.

^cDepending on mast cell source (rat or RBL cell line).