Table 4.

Tissue distribution of IgE receptors in humans vs animal models in AllergoOncology

Human	Basophils, mast cells, eosinophils, monocytes, dendritic cells, Langerhans cells Reviewed in: Daniels TR et al. Cancer Immunol Immunother 2012;61(9):1535–1546	Monocytes, eosinophils, B cells, T cells, dendritic cells, Langerhans cells, platelets Rev. in: Daniels TR et al. Cancer Immunol Immunother 2012;61(9):1535–1546
Mouse (wt)	Basophils, mast cells Rev. in: Daniels TR et al. Cancer Immunol Immunother 2012;61(9):1535–1546	μ+, δ+ B cells, some CD8+ T‐cell subsets Delespesse G et al. Immunol Rev 1992 Feb;125:77–97
Mouse (transgenic)
mFcεRIα−/− , hFcεRIαTg, C57BL/6 background Dombrowicz D et al. Immunity 1998;8(4):517–529	hFcεRIα on bone marrow‐derived mast cells Dombrowicz D et al. J Immunol 1996 Aug 15;157(4):1645–51		mFcεRIα is replaced with hFcεRIα, which complexes with murine FcRβ and FcRγ subunits
hFcεRIαTg, C57BL/6J background Fung‐Leung WP et al. J Exp Med 1996 Jan 1; 183(1): 49–56	hFcεRIα on bone marrow‐derived mast cells Fung‐Leung WP et al. J Exp Med 1996 Jan 1; 183(1): 49–56. PMCID: PMC2192401		hFcεRIα complexes with murine FcRβ and FcRγ subunits
Model 1: mFcεRIα−/− , hFcεRIαTg Model 2: mFcεRIα−/− , mFcRβ−/− , hFcεRIαTg, BALB/c background Dombrowicz D et al. Immunity, Volume 8, Issue 4, 1 April 1998, Pages 517–529	Mast cells, basophils, monocytes, eosinophils, Langerhans cells Dombrowicz D et al. Immunity, Volume 8, Issue 4, 1 April 1998, Pages 517–529		mFcεRIα is replaced with hFcεRIα, which complexes with murine FcRβ and/or FcRγ subunits
Rat	Basophils, mast cells, macrophages, eosinophils Daniels TR et al. Cancer Immunol Immunother 2012;61(9):1535–1546	B cells, macrophages Capron A et al. Eur J Immunol 1977 May;7(5):315–22 Mencia‐Huerta JM et al. Int Arch Allergy Appl Immunol 1991;94(1–4):295–8
Dog	Basophils, tissue mast cells, monocytes, Langerhans cells, CD1+ dendritic cells Jackson HA et al. Veterinary Immunology and Immunopathology, Volume 85, Issues 3–4, March 2002, Pages 225–232	Eosinophils Galkowska H et al. Veterinary Immunology and Immunopathology, Vol 53, Issues 3–4, October 1996, Pages 329–334	Data not complete, sometimes not evident if expression relates to FcεRI or CD23