Table 5.

Brigham and Women's Hospital three‐bag 12‐step desensitization protocol for paclitaxel 300 mg

Target dose (mg)	300
Standard volume per bag (ml)	250
Final rate of infusion (ml/h)	80
Calculated target concentration (mg/ml)	1.2
Standard time of infusion (min)	187.5
	Volume		Concentration (mg/ml)		Total mg per bag	Amount infused (ml)
Solution 1	250	ml of	0.012	mg/ml	3	9.38
Solution 2	250	ml of	0.120	mg/ml	30	18.75
Solution 3	250	ml of	1.190	mg/ml	297.638	250
Note: The total volume and dose dispensed are more than the final dose given to patient because many of the solutions are not completely infused
Step	Solution	Rate (ml/h)	Time (min)	Volume infused per step (ml)	Dose administered with this step (mg)	Cumulative dose (mg)
1	1	2.5	15	0.63	0.0075	0.0075
2	1	5	15	1.25	0.015	0.0225
3	1	10	15	2.5	0.03	0.0525
4	1	20	15	5	0.06	0.1125
5	2	5	15	1.25	0.15	0.2625
6	2	10	15	2.5	0.3	0.5625
7	2	20	15	5	0.6	1.1625
8	2	40	15	10	1.2	2.3625
9	3	10	15	2.5	2.9764	5.3389
10	3	20	15	5	5.9528	11.2916
11	3	40	15	10	11.9055	23.1971
12	3	80	174.375	232.5	276.8029	300
Total time: 5.66 h