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. 2017 May 31;13(5):154–159. doi: 10.6026/97320630013154

Table 1. Antimalarial drugs with targets.

Pathway /Process Targets Drugs Source(s)
Replication GyrA, GyrB Fluoroquinolone, Ciprofloxacin, Clindamycin, Doxycycline, Novobiocin, Coumermycin,chloroquine [15],[18],[19],[31], [32]
Transcription RpoB, RpoC1, RpoC2 Rifampin, Thiostrepton, Doxycycline, Tetracycline, Clindamycin [16],[18],[33][33], [34]
Translation Pf1F-1, 23s rRNA, GTPase, Aminoacyl tRNA - synthetase,PTC Macrolides, Thiostrepton, Chloramphenicol, Lincosamides, Micrococcin, Mupirocin,Indolmycin [17],[18],[20],[35], [36]
Fatty acid biosynthesis FASII, FabH, FabI, β-ketoacyl-ACP sythetase I and II Thiolactomycin, Cerulenin, Triclosan [18]
Isoprenoid synthesis DOXP reductoisomerase Fosmidomycin [12]
Heme Synthesis Dehydratases Herbicides [13],[14]