Figure 2.

Nanoparticle Accumulation within the Tumor Parenchyma

Small nanoparticles passively cross the endothelial fenestrations and accumulate in a perivascular position. Sub-micrometric and micrometric nanoconstructs, which are sufficiently deformable, adhere to the vessel walls and could squeeze in through fenestrations. Therefore, both small nanoparticles and deformable particles would expose their therapeutic cargo to the tumor parenchyma from a perivascular position.