Table 1.
Invasive hemodynamic parameters
| Young Baseline (n=6) | Aging baseline (n=6) | Young day 3 post-TAC (n=6) | Aging day 3 post-TAC (n=7) | |
|---|---|---|---|---|
| SV (μL) | 12.3±5.0 | 14.4±4.87 | 6.27±2.85* | 8.8±5.2* |
| SVI (μL g-1) | 0.58±0.23 | 0.43±0.13 | 0.31±0.14* | 0.28±0.17 |
| ESV (μL) | 14.3±1.8 | 18.7±4.0§ | 10.8±3.8 | 8.2±3.2* |
| ESVI (μL g-1) | 0.67±0.07 | 0.57±0.11 | 0.53±0.19 | 0.27±0.10*,§ |
| EDV (μL) | 22.1±7.8 | 29.6±7.6 | 13.0±4.7* | 14.1±6.7* |
| EDVI (μL g-1) | 1.04±0.35 | 0.91±0.21 | 0.64±0.23* | 0.46±0.22* |
| Cardiac index (ml min-1 × kg) | 238±102 | 175±59 | 166±95 | 127±89 |
| HR (min-1) | 407±21 | 401±82 | 522±75* | 430±69§ |
| EF (%) | 51±5 | 47±9 | 46±10 | 57±13 |
| Pdev (mmHg) | 78.6±9.4 | 69.2±9.3 | 82.8±15.4 | 83.0±6.4* |
| Ea (mm Hg μl-1) | 7±3 | 5±2 | 16±8 | 15±14 |
| dP/dTmax (mm Hg s-1) | 6138±1175 | 5055±1277 | 4741±1527 | 5045±1449 |
| dP/dTmin (mm Hg s-1) | 5841±1886 | 4781±1540 | 5378±2242 | 5865±1751 |
| Ees (mm Hg μl-1) | 1.77±1.15 | 1.33±0.87 | 0.67±2.23 | 2.47±0.95§ |
| V0 (μL) | 54.35±9.48 | 36.26±8.19 | 67.68±30.95 | 42.46±16.11§ |
| SWI (mm Hg ml g-1) | 36.95±20.5 | 25.5±9.4 | 17.9±15.5* | 19.1±13.4 |
| Tau (ms) | 8.6±1.9 | 9.4±2.4 | 11.5±5.6 | 9.0±5.6 |
| EDPVR | 0.06±0.04 | 0.04±0.02 | 0.026±0.097 | 0.056±0.03 |
| Body weight (g) | 21.2±0.74 | 32.5±1.37§ | 20.2±0.23* | 30.8±0.92*,§ |
SV = stroke volume. SVI = stroke volume index. ESV = end-systolic volume. ESVI = end-systolic volume index. EDV = end-diastolic volume. EDVI = end-diastolic volume index. HR = heart rate. EF = ejection fraction. Pdev = developed pressure. SWI = stroke work index. EDPVR = end-diastolic pressure volume relation. V0 = intercept of the Volume axis. Ea = arterial elastance. dP/dT max = maximal rise in pressure. dP/dT min = maximal rate of pressure decline. Ees = end-systolic elastance.
*
P<0.05 vs respective baseline.
§
P<0.05 young vs aging at same time-point.