Table 4.
mRNA expression of genes coding for selected nucleolar and ribosomal proteins, rRNA18S and rRNA28S in frontal cortex area 8 in MA, AD and rpAD
| MA | AD | rpAD | MA vs AD | MA vs rpAD | AD vs rpAD | |
|---|---|---|---|---|---|---|
| UBTF | 1.069 ± 0.444 | 0.602 ± 0.124 | 0.574 ± 0.085 | *↓ | **↓ | - |
| NPM1 | 1.078 ± 0.476 | 0.531 ± 0.077 | 0.593 ± 0.144 | **↓ | *↓ | - |
| NCL | 1.083 ± 0.472 | 0.646 ± 0.098 | 0.673 ± 0.123 | *↓ | *↓ | - |
| rRNA18S | 1.038 ± 0.270 | 0.702 ± 0.303 | 0.578 ± 0.126 | *↓ | ***↓ | - |
| rRNA28S | 1.113 ± 0.617 | 0.423 ± 0.230 | 0.385 ± 0.085 | **↓ | *↓ | - |
| RPL5 | 1.008 ± 0.130 | 1.010 ± 0.165 | 1.039 ± 0.155 | - | - | - |
| RPL7 | 1.007 ± 0.120 | 1.029 ± 0.183 | 1.091 ± 0.051 | - | - | - |
| RPL21 | 1.085 ± 0.492 | 1.606 ± 0.559 | 1.606 ± 0.545 | *↑ | *↑ | - |
| RPL22 | 1.013 ± 0.165 | 0.835 ± 0.139 | 0.855 ± 0.083 | *↓ | *↓ | - |
| RPL23A | 1.044 ± 0.318 | 1.140 ± 0.179 | 1.482 ± 0.363 | - | *↑ | *↑ |
| RPL26 | 1.020 ± 0.195 | 0.992 ± 0.295 | 0.947 ± 0.237 | - | - | - |
| RPL27 | 1.009 ± 0.141 | 1.007 ± 0.129 | 0.746 ± 0.630 | - | - | - |
| RPL30 | 1.032 ± 0.266 | 1.097 ± 0.547 | 0.921 ± 0.404 | - | - | - |
| RPL31 | 1.010 ± 0.148 | 1.002 ± 0.115 | 1.170 ± 0.161 | - | *↑ | *↑ |
| RPS3A | 1.031 ± 0.271 | 1.119 ± 0.423 | 0.919 ± 0.310 | - | - | - |
| RPS5 | 1.006 ± 0.110 | 1.071 ± 0.209 | 1.261 ± 0.155 | - | ***↑ | - |
| RPS6 | 1.009 ± 0.134 | 1.255 ± 0.375 | 1.430 ± 0.373 | *↑ | **↑ | - |
| RPS10 | 1.017 ± 0.191 | 1.223 ± 0.131 | 1.324 ± 0.242 | *↑ | **↑ | - |
| RPS13 | 1.002 ± 0.072 | 1.031 ± 0.069 | 1.255 ± 0.217 | - | **↑ | *↑ |
| RPS16 | 1.019 ± 0.205 | 1.020 ± 0.243 | 0.845 ± 0.283 | - | - | - |
| RPS17 | 1.004 ± 0.091 | 1.035 ± 0.133 | 1.252 ± 0.192 | - | **↑ | *↑ |
| RPS20 | 1.008 ± 0.140 | 0.819 ± 0.132 | 0.674 ± 0.234 | **↓ | **↓ | - |
The non-parametric Mann-Whitney test was performed to compare each group when the samples did not follow a normal distribution whereas the unpaired t test was used for normal variables. Data are represented as the mean ± SD: *P<0.05, **P<0.01 and ***P<0.001. ↓, ↑ indicate gene up-regulation and down-regulation, respectively.