Table 2.
Prognostic implications of linitis plastica in the literature
| Author, year | Study design | LP sample size | Stage (%) | pT1/2/3/4 (%) | pN0/1/2/3 (%) | M1 (%) | CY1 (%) | P1 (%) | Surgical resection (%) | Total gastrectomy (%) | R1/R2 (%) | Median survival (months) | Median survival unresected (months) | Median survival resected (months) | Median survival R0 (months) | 1Y-OS (%) | 3Y-OSS (%) | 5Y-OS (%) | Impact of LP on prognosis after adjustment |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aranha, 1989 [76] | Retrospective cohort | 26 | – | – | – | – | – | – | 50 | 85 | – | 6.9 | 6.6 | 7.2 | – | – | – | – | Not performed |
| Hamy, 1999 [77] | Retrospective cohort | 86 | – | 5.5(T1 + T2)/4/90.5 | – | – | – | – | 86 | 69 | – | – | – | 12 | – | 50d | 40d | 10d | Not performed |
| Kodera, 2004 [70] | Retrospective cohort | 47 | – | 0/2/72/26 | 2/13/23/45 | – | 43 | 43 | 83 | – | 47 | 14 | 10 | Not performed | |||||
| Kodera, 2008 [75] | Retrospective cohort | 178 | – | -/-/-/89 | 15/23/21/41 | – | – | 44 | 84 | 77 | 45 | 13.8 | 7.8 | – | 30.2 | – | – | – | Not performed |
| Schauer, 2011 [15] | Retrospective cohort | 120 | – | 0/0/65/35 | 13/19/18/50 | H1: 10%; LYMPH1: 20% |
16 | 33 | 100 | 62.5 | 69 | 8 | – | 8 | 17 | – | – | 8d | Not performed |
| Endo, 2012 [16] | Retrospective cohort | 19 | 5/5/58/32 | 0/11/68/21 | N+: 89.5% | – | 53 | 46 | 100 | – | – | 9a | – | 9a | – | 26d | 21d | 7d | Not performed |
| Pedrazzani, 2012 [14] | Retrospective cohort | 102 | – | 0/78(T2 + T3)/22 | 4/37/42/17 | – | – | – | 59 | – | 31 | 5.7 | 2.8 | – | 16 | 68e | 14e | 4e | Not performed |
| Jafferbhoy, 2013 [19] | Case series | 8 | – | – | – | 25 | – | 0 | – | – | – | – | – | – | – | – | – | Not performed | |
| Blackham, 2016 [17] | Retrospective cohort | 58 | III-IV: 90% | 2/2/43/53 | 15/14/28/43 | – | – | – | 100 | 88 | 34 | 11.6 | – | 11.6 | 21.5a | – | 24d | 15d | Nob |
| Thompson, 2016 [78] | Retrospective cohort | 54 | – | 6/12/53/29 | 24/24/6/41 | 52 | – | – | 31 | – | 35 | – | 3.6 | 16.7 | – | – | – | – | Noc |
1Y-OS 1-year overall survival, 3Y-OS 3-year overall survival, 5Y-OS 5-year overall survival
aExtracted from the Kaplan-Meier curve
bAdjustment by stage and optimal resection status in comparison with non-LP patients
cAdjustment by optimal resection status in comparison with non-LP patients
dAfter resection
eAfter R0 resection