Table 4.

Univariate and Multivariate Analysis of Predictors of Incisional Surgical Site Infection

Variable	n	Odds ratio	95% CI	p Value
Univariate factors for superficial/deep SSI
Dressing type (SSD vs NPWT)	265	1.01	0.52–1.95	>0.99
Age	265	1.15	0.99–1.34	0.064
Sex, female	265	0.81	0.41–1.58	0.53
Race	260	0.31	0.07–1.35	0.12
Eastern Cooperative Oncology Group	245	1.23	0.70–2.18	0.47
BMI	265	1.04	0.99–1.10	0.12
Diabetes	264	1.41	0.67–2.95	0.36
COPD	264	2.17	0.73–6.45	0.16
Renal failure	262	0.57	0.07–4.63	0.6
Hypertension	265	1.43	0.75–2.89	0.26
Cardiovascular disease	264	2.00	0.89–4.48	0.093
Previous abdominal surgery	265	1.62	0.82–3.19	0.17
Smoking	263	2.33	1.17–4.67	0.017
Preoperative chemotherapy	261	1.44	0.70–2.97	0.32
Preoperative radiation	265	2.31	0.84–6.37	0.1
Preoperative albumin	250	0.88	0.82–0.95	0.0006
American Society of Anesthesiologists class*	265
2 vs 4		1.37	0.29–6.48	0.69
3 vs 4		0.75	0.20–2.77	0.66
2 vs 3		1.83	0.68–4.92	0.23
Type of operation†	265
GI vs pancreatic		1.16	0.51–2.63	0.72
CRS/HIPEC vs pancreatic		0.35	0.15–0.78	0.011
CRS/HIPEC vs GI		0.3	0.13–0.70	0.0052
Operative time, h	265	1.02	0.91–1.15	0.74
Estimated blood loss	263	1.01	0.95–1.08	0.69
Units of blood transferred	265	0.98	0.66–1.44	0.91
Laparoscopic-assisted	265	1.06	0.12–9.03	0.96
Best fit multivariate factors for superficial/deep incisional SSI
Preoperative albumin	250	0.89	0.83–0.96	0.0031
Type of operation‡	250
GI vs pancreatic		1.56	0.65–3.73	0.32
HIPEC vs pancreatic		0.44	0.18–1.06	0.067
HIPEC vs GI		0.28	0.12–0.69	0.0052

^*Overall p = 0.47.

^†Overall p = 0.0086.

^‡Overall p = 0.018.

CRS, cytoreductive surgery; GI, gastrointestinal; HIPEC, hyperthermic intraperitoneal chemotherapy; NPWT, negative-pressure wound therapy; SSI, surgical site infection; SSD, standard surgical dressing.