Table 1.
Multivariable*$ associations between patient demographics and disease characteristics with survival after recurrence (SAR), adjusting for biomarkers (MMR, KRAS, and BRAF).
| Biomarkers | N of patients (%) | HR | 95% CI | P-value |
|---|---|---|---|---|
| Age, 10 year increase | 832 | 1.06 | 0.98-1.15 | 0.17 |
|
| ||||
| Sex | ||||
| Female | 387 (46.5%) | 0.90 | 0.76-1.06 | 0.21 |
| Male | 445 (53.5%) | Ref | ||
|
| ||||
| Performance Score | ||||
| 0 | 629 (75.6%) | Ref | ||
| 1 | 198 (22.7%) | 1.23 | 1.01-1.49 | 0.037 |
| 2 | 5 (0.6%) | 7.97 | 3.19-19.88 | <.0001 |
|
| ||||
| T-stage | ||||
| T1/2 | 47 (5.6%) | Ref | ||
| T3 | 631 (75.8%) | 1.32 | 0.88-1.99 | 0.1794 |
| T4 | 154 (18.5%) | 1.41 | 0.91-2.19 | 0.1264 |
|
| ||||
| N-stage | ||||
| N1 | 339 (40.7%) | Ref | ||
| N2 | 493 (59.3%) | 1.39 | 1.17-1.66 | 0.0002 |
|
| ||||
| Primary tumor site | ||||
| Distal | 384 (46.2%) | 0.70 | 0.58-0.84 | 0.0002 |
| Proximal | 448 (53.8%) | Ref | ||
|
| ||||
| Histologic grade | ||||
| Low grade (1-2) | 587 (70.6%) | Ref | ||
| High grade (3/4/anaplastic) | 245 (29.4%) | 1.40 | 1.17-1.68 | 0.0003 |
|
| ||||
| Time-to-recurrence, 1 year increase | 832 | 0.79 | 0.72-0.87 | <.0001 |
Abbreviations: HR, hazard ratio; CI, confidence interval.
*
Multivariable model in 832 patients includes complete data on all covariates (age, sex, performance score, T-stage, N-stage, primary tumor site, histologic grade, time-to-recurrence, MMR, KRAS, and BRAF. The HR, 95% CI and p-value associated with MMR, KRAS, BRAF are presented in Table 2.
$
Stratified Cox models with four treatment arms as individual strata.