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. 2017 Jul 5;19:158. doi: 10.1186/s13075-017-1364-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Immunohistological comparison of the expression of CD4+ and forkhead box protein transcription factor 3-positive (FOXP3+) T cells (magnification × 10) in the synovial tissue prior to and at 6 months after abatacept treatment (patient #6). Baseline images show focal infiltration of CD4+ T cells (a) and FOXP3+ T cells (b) in a villus. Decrease in CD4 expression and significant reduction in the number of FOXP3+ T cells are shown (c and d, respectively)